| 慢性应激对不同性别小鼠空间认知能力的影响 |
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| 作者姓名： | Han Y Shi RH Wang XJ Xie M Wang SH Liao XM |
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| 作者单位： | 华中师范大学生命科学学院神经生物学实验室遗传调控与整合生物学湖北省重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(30700208,30800329); 武汉市青年科技晨光计划(200850731362); 华中师范大学科研项目资助(091301009) |
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| 摘 要： | 目的:探讨慢性应激对不同性别小鼠空间认知能力的影响.方法:成年健康昆明小鼠32只,平均分为4组(n=8):雄性对照组和雄性应激组,雌性对照组和雌性应激组.研究采用改良的Kaz法,建立慢性应激小鼠模型,利用Morris水迷宫进行定位航行和空间搜索实验,观察不同性别的小鼠空间认知能力的改变.结果:经2周的应激处理后,在定位...
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| 关 键 词： | 慢性应激 水迷宫 空间认知能力 性别差异 |
The effects of chronic stress on spatial cognitive ability of different sex mice |
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| Han Y,Shi RH,Wang XJ,Xie M,Wang SH,Liao XM.The effects of chronic stress on spatial cognitive ability of different sex mice[J].Chinese Journal of Applied Physiology,2011,27(3):265-269. |
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| Authors: | Han Yun Shi Rui-hong Wang Xin-jia Xie Min Wang Shao-hui Liao Xiao-mei |
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| Institution: | HAN Yun,SHI Rui-hong,WANG Xin-jia,XIE Min,WANG Shao-hui,LIAO Xiao-mei(College of Life Science and Hubei Key Laboratory of Genetic Regulation and Integrative Biology,Central China Normal University,Wuhan 430079,China) |
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| Abstract: | Objective:To investigate the effects of chronic stress on spatial cognitive ability in different sex mice.Methods: Thirty-two adult KM mice were divided into four groups(n=8): male control and chronic stress group,female control and chronic stress group.We used the modified Kaz's methods to build on the chronic stress model of mice,and then used the place navigational testing and the probe trial testing by the Morris water maze to measure the spatial cognitive ability of mice.Results: Following two weeks st... |
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| Keywords: | chronic stress water maze spatial cognitive ability sex difference |
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