Nucleosidyl-O-Methylphosphonates: a pool of monomers for modified oligonucleotides |
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Authors: | Rejman Dominik Masojídková Milena Rosenberg Ivan |
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Institution: | Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague 6, Czech Republic. |
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Abstract: | An unique set of 5'-O- and 3'-O-phosphonomethyl derivatives of four natural 2'-deoxyribonucleosides, 1-(2-deoxy-beta-D-threo-pentofuranosyl)thymine, 5'-O- and 2'-O-phosphonomethyl derivatives of 1-(3-deoxy-beta-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-beta-D-threo-pentofuranosyl)thymine, has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step. |
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