Effect of adjuvant-induced arthritis on serum luteinizing hormone and testosterone concentrations in the male rat |
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| Authors: | B C Bruot J W Clemens |
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| Institution: | 1. Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Changsha, Hunan 410008, China;3. Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, China;1. Departments of Radiology, Cancer Center, New York, NY, United States of America;2. Epidemiology & Biostatistics, Memorial Sloan Kettering, Cancer Center, New York, NY, United States of America;1. Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Gambang, 26300 Kuantan, Malaysia;2. Chemistry Department, Faculty of Science, Al–Azhar University, Assiut 71524, Egypt;3. Department of Physics, Faculty of Sciences, King Khalid University, P. O. Box 9004, Abha, Saudi Arabia;4. Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61413, P. O. Box 9004, Saudi Arabia |
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| Abstract: | Male Lewis rats were made arthritic by injecting 1 mg Mycobacterium butyricum suspended in Freund's incomplete adjuvant into their right hind footpad. Arthritic and non-arthritic animals were sacrificed on days 18, 21, 24 or 27 after the injection of the adjuvant. Body weight, left and right hind paw volume, thymus weight, and serum luteinizing hormone (LH) and testosterone concentrations were determined on each day. Adjuvant injection resulted in a significant enlargement in the left and right hind paws on days 18 through 27. In contrast, body and thymus weights were reduced significantly in the arthritic rats compared to the non-arthritic animals. Serum concentrations of testosterone were also reduced significantly in arthritic rats on days 18, 21 and 24 after the injection of the adjuvant. However, by day 27 serum testosterone concentrations recovered to near control values. Serum concentrations of LH in the arthritic animals were elevated on days 18 through 27. These results demonstrate that serum testosterone concentrations were reduced in rats with adjuvant-induced arthritis. The reduction in serum testosterone is probably not the result of an impaired hypothalamic-pituitary axis. |
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