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A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks |
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| Authors: | Ajit C Tamhane Jiangtao Gou Christopher Jennison Cyrus R Mehta Teresa Curto |
| Institution: | 1. Department of Industrial Engineering and Management Sciences, Northwestern University, Evanston, Illinois 60208, U.S.A.;2. Department of Mathematics and Statistics, Hunter College, New York, New York 10065, U.S.A.;3. Department of Mathematical Sciences, University of Bath, Bath BA2 7AY, UK;4. Cytel Inc., 675 Massachusetts Avenue, Cambridge, Massachusetts 02139, U.S.A. |
| Abstract: | |
| Keywords: | Familywise error rate Gatekeeping Lan– DeMets error spending function approach Multiple comparisons Multiple endpoints O'Brien– Fleming boundary Pocock boundary Primary power Secondary power |