A sheer pharmacologic approach to compare the contractile effects of PGF2alpha, DL-cloprostenol and D-cloprostenol on isolated uterine, tracheal, ileal and arterial smooth muscle preparations |
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| Authors: | Beretta C Cavalli M |
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| Affiliation: | Department of Clinical Veterinary Sciences, University of Milan, Via Celoria 10, Milan 20133, Italy. |
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| Abstract: | The contractile effects of PGF2alpha and its cloprostenol analogs (D-enantiomer and racemate) were examined on isolated smooth muscle preparations (uterine, tracheal, ileal and arterial) from rat, guinea-pig and horse. DL- and D-cloprostenol were potent contractors of myometrium, but had negligible secondary effects on other types of smooth muscle, except artery whose response to the D-enantiomer may give rise to some concern. |
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