Genetic control of immunoglobulin allotypes in the fowl |
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| Authors: | C. S. David M. L. Kaeberle A. W. Nordskog |
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| Affiliation: | (1) Department of Poultry Science, Iowa State University, Ames, Iowa;(2) Department of Veterinary Microbiology, Iowa State University, Ames, Iowa;(3) Present address: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan |
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| Abstract: | Eight immunoglobulin allotypic specificities have been identified in the fowl by isoimmunization. Aa1 and Aa2 are controlled as codominants at the a locus, Ab1 and Ab2 at the b locus, and Ac1, Ac2, Ac3, and Ac4 at the c locus. Column chromatography and ultracentrifugation indicate that the specificities at the a locus are located on molecules corresponding to IgG with sedimentation coefficients 7 S. Immunoelectrophoresis results also indicate that we are dealing with an immunoglobulin G molecule. Further tests are underway to resolve this beyond doubt.Journal Paper No. 5405 of the Iowa Agricultural and Home Economics Experiment Station, Ames, Iowa. Project 1039. Supported in part by National Science Foundation Grants GB 318 and GB 4450. |
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