Naloxone increases pain perception in rats and mice. |
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| Authors: | J J Carmody P R Carroll D Morgans |
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| Affiliation: | School of Physiology and Pharmacology The University of New South Wales Kensington N.S.W. 2033, Australia |
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| Abstract: | Rats and mice manifest hyperalgesia when treated with low doses of naloxone. These doses are sufficient to block morphine analgesia. The results are consistent with the hypothesis that there is physiological release of an endogenous opioid which modulates pain sensitivity. |
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