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The discovery and synthesis of highly potent, A2a receptor agonists |
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| Authors: | Keeling S E Albinson F D Ayres B E Butchers P R Chambers C L Cherry P C Ellis F Ewan G B Gregson M Knight J Mills K Ravenscroft P Reynolds L H Sanjar S Sheehan M J |
| Affiliation: | Medicinal Sciences, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts, UK. ser0079@glaxowellcome.co.uk |
| Abstract: | A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A2a and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A2a receptor on the human neutrophil. |
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