A putative novel alpha/beta hydrolase ORFan family in Bacillus |
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Authors: | Siew Naomi Saini Harpreet Kaur Fischer Daniel |
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Institution: | Department of Chemistry, Ben Gurion University, Beer-Sheva 84105, Israel. |
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Abstract: | A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the alpha/beta hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the alpha/beta hydrolase superfamily to which they may belong. |
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Keywords: | ORFans Fold recognition Structure prediction Alpha/beta hydrolase Bacillus |
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