Diazepam phase shifts the circadian clock of the field mouseMus booduga |
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Authors: | P Subramanian R Subbaraj |
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Institution: | (1) Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, 625 021 Madurai, India |
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Abstract: | Single 2h administration of diazepam (benzodiazepine) in 3.5% ethanol solution was found to evoke advance and delay phase
shifts in the locomotor activity rhythm in the field mouseMus booduga. Through such pulsed administration of diazepam at various phases of circadian rhythm a phase response curve could be constructed.
Phase advance occurred during early subjective day (CT 2) and phase delays were observed in the remaining phases. The shape
of the diazepam phase response curve is similar to the general shape of the phase response curves generated by intraperitoneal
injections of other benzodiazepines in hamsters. The phase shifting action of diazepam may be explained by its agonistic action
on the neurotransmitter gamma-aminobutyric acid. |
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Keywords: | Phase response curve diazepam gamma-aminobutyric acid Mus booduga |
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