Histone deacetylases as transducers and targets of nuclear signaling |
| |
Authors: | Walkinshaw Donald R Tahmasebi Soroush Bertos Nicholas R Yang Xiang-Jiao |
| |
Affiliation: | Molecular Oncology Group, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1. |
| |
Abstract: | Histone deacetylase (HDAC) activity was first discovered about 40 years ago, but it was not until the molecular identification of the first HDACs in 1996 that this family of enzymes gained prominence. In addition to histones, HDACs reverse lysine acetylation of various non-histone proteins located in the nucleus and the cytoplasm. Here, we examine the nuclear roles of these enzymes, with a specific focus on their active crosstalk with different chromatin regulators. |
| |
Keywords: | lysine deacetylase Rpd3 Hda1 Sir2 SIRT1 MEF2 HDAC inhibitor |
本文献已被 PubMed 等数据库收录! |
|