| 猪链球菌2型89K毒力岛研究进展 |
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| 引用本文： | 朱静,王长军.猪链球菌2型89K毒力岛研究进展[J].微生物学通报,2013,40(8):1487-1492. |
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| 作者姓名： | 朱静 王长军 |
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| 作者单位： | 南京军区军事医学研究所 江苏 南京210002;南京医科大学基础医学院 江苏 南京210029 |
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| 基金项目： | 国家自然科学基金项目(No. 31170124, 30972638, 81071317, 81171527, 81172794); 江苏省自然科学基金资助项目(No. BK2011097, BK2011098) |
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| 摘 要： | 高致病性猪链球菌2型的致病机制仍是未解之谜.毒力岛不仅赋予病原菌特殊的致病能力,而且在细菌的适应性进化过程中扮演重要角色.对猪链球菌2型89K毒力岛功能性基因的深入剖析有助于更全面地掌握病原菌的致病特性.综述了猪链球菌2型89K毒力岛的结构与进化过程,以及国内外对毒力岛中二元信号转导系统、Ⅳ型分泌系统、ABC转运蛋白、毒素-抗毒素系统等重要基因的研究进展,力图从基因水平为猪链球菌2型的致病机制寻找突破口.
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| 关 键 词： | 猪链球菌 2型 89K 毒力岛 进展 |
Research progress on 89K pathogenicity island of Streptococcus suis serotype 2 |
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| ZHU Jing and WANG Chang-Jun.Research progress on 89K pathogenicity island of Streptococcus suis serotype 2[J].Microbiology,2013,40(8):1487-1492. |
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| Authors: | ZHU Jing and WANG Chang-Jun |
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| Institution: | 1. Research Institute for Medicine of Nanjing Command, Nanjing, Jiangsu 210002, China 2. School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 210029, China |
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| Abstract: | The pathogenic mechanism of Streptococcus suis serotype 2 is still unsolved. Pathogenicity island not only gives pathogen special ability of pathogenic but also plays an important role in bacterial evolution process. Thorough analysis of the functional genes in 89K pathogenicity island contributes to a more comprehensive grasp of the characteristics of Streptococcus suis serotype 2. This paper summarized the structure and evolution process of 89K pathogenicity island and the research progress of domestic and foreign, including in two-component signal transduction system, type IV secretion system, ATP-binding cassette transporter protein, toxin-antitoxin system and other important genes, trying in gene level to find a breakthrough in pathogenesis of Streptococcus suis serotype 2. |
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| Keywords: | Streptococcus suis serotype 2 89K pathogenicity island research progress |
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