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Antibacterial activity of quinolone-macrocycle conjugates |
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| Authors: | Jefferson Elizabeth A Swayze Eric E Osgood Stephen A Miyaji Alycia Risen Lisa M Blyn Lawrence B |
| Affiliation: | Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA. ejeffers@isisph.com |
| Abstract: | Novel quinolone-macrocycle conjugates displayed submicromolar antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains. An analogous open-chain structure was not active at 100 microM against the same pathogenic strains. |
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