Microglial activation in different models of peripheral nerve injury of the rat |
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Authors: | Stanislava Jergová Dáša Čížková |
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Institution: | (1) Institute of Neurobiology, Slovak Academy of Sciences, 04001 Kosice, Slovak Republic |
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Abstract: | Pain and pain modulation has been viewed as being mediated entirely by neurons. However, new research implicates spinal cord
glia as key players in the creation and maintenance of pathological pain. Sciatic nerve lesions are one of the most commonly
studied pain-related injuries. In our study we aimed to characterize changes in microglial activation in the rat spinal cord
after axotomy and chronic constriction injury of the sciatic nerve and to evaluate this activation in regard to pain behavior
in injured and control groups of rats. Microglial activation was observed at ipsilateral side of lumbar spinal cord in all
experimental groups. There were slight differences in the level and extent of microglial activation between nerve injury models
used, however, differences were clear between nerve-injured and sham animals in accordance with different level of pain behavior
in these groups. It is known that activated microglia release various chemical mediators that can excite pain-responsive neurons.
Robust microglial activation observed in present study could therefore contribute to pathological pain states observed following
nerve injury. |
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Keywords: | Peripheral nerve injury Neuropathic pain Allodynia Microglia |
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