alpha-Tocopherol increases phosphorylation of rat nuclear proteins,catalyzed by protein kinase C |
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Authors: | Petrova G V Donchenko G V |
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Affiliation: | Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. |
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Abstract: | alpha-Tocopherol added in vivo increased protein kinase C--dependent phosphorylation of rat liver nuclei proteins. Such effect of tocopherol was found also after the addition of sphingosine known as natural inhibitor of protein kinase C to incubation medium. The stimulation of phosphorilation was observed also after the addition of alpha-tocopherol to the Triton X-100 solubilized nuclear fraction which contained protein kinase C and tocopherol-binding proteins. |
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