Increased amounts of small polydisperse circular DNA (spcDNA) in angiofibroma-derived cell cultures from patients with tuberous sclerosis (TS) |
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| Authors: | C. Neidlinger G. Assum W. Krone C. Dietrich R. Hochsattel G. Klotz |
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| Affiliation: | (1) Abteilung Humangenetik der Universität, Postfach 4066, D-7900 Ulm, Germany;(2) Abteilung für Dermatologie der Universität, Postfach 4066, D-7900 Ulm, Germany;(3) Abteilung Virologie der Universität, Postfach 4066, D-7900 Ulm, Germany |
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| Abstract: | Summary Much greater amounts of small polydisperse circular DNA (spcDNA) have been detected, in cell cultures derived from angiofibromas of six patients with tuberous sclerosis (TS) than in those from the skin of these patients or from the skin of 11 healthy donors. This observation could be confirmed by spreading the DNA of appropriate fractions from CsCl density gradients. The findings suggest the existence of a relationship between the chromosomal instability observed in angiofibroma cultures and the mobilization of spcDNA. |
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