Synthesis of a new class of HIV-1 inhibitors |
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Authors: | Farese-Di Giorgio A Pairot S Patino N Condom R Di Giorgio C Aumelas A Aubertin A M Guedj R |
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Affiliation: | Laboratoire de Chimie Bio-Organique, CNRS ESA 6001, Université de Nice Sophia-Antipolis, France. |
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Abstract: | A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without cellular toxicity until 200 microM concentration. |
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