Myc-1 is centromeric to the linkage group Ly-6--Sis--Gdc-1 on mouse chromosome 15 |
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| Authors: | Konrad Huppi Robert Duncan Michael Potter |
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| Institution: | (1) Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20892 Bethesda, MD, USA |
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| Abstract: | A survey of wild mouse DNA with a c-myc exon 1 probe revealed a Taq I restriction fragment length polymorphism (RFLP) among Mus species. As a result of this Taq I RFLP, a cross between Mus musculus domesticus and BALB/cJ permitted the positioning of Myc-1 on chromosome 15 with respect to Ly-6, Sis, and Gdc-1. Compilation of the recombination frequency generated from this cross with published cytogenetic and plasma-cytoma somatic cell hybrid data suggests the following chromosome 15 orientation: centromere--Myc-1--Ly-6--Sis--Gdc-1--telomere. This gene order is consistent with conservation of man-mouse synteny. |
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