Presynaptic Nicotinic Cholinergic Receptors Labeled by [3H]Acetylcholine on Catecholamine and Serotonin Axons in Brain |
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Authors: | Rochelle D. Schwartz John Lehmann Kenneth J. Kellar |
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Affiliation: | Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C.;Division of Child Psychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A. |
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Abstract: | Nicotinic cholinergic receptor binding sites labeled by [3H]acetylcholine were measured in the cerebral cortices, thalami, striata, and hypothalami of rats lesioned by intraventricular injection of either 6-hydroxydopamine or 5, 7-dihydroxytryptamine. In addition, [3H]acetylcholine binding sites were measured in the cerebral cortices of rats lesioned by injection of ibotenic acid into the nucleus basalis magnocellularis. [3H]Acetylcholine binding was significantly decreased in the striata and hypothalami of both 6-hydroxydopamine- and 5,7-dihydroxytryptamine-lesioned rats. There was no change in binding in the cortex or thalamus by either lesion. Ibotenic acid lesions of the nucleus basalis magnocellularis, which projects cholinergic axons to the cortex, did not alter [3H]acetylcholine binding. These results provide evidence for a presynaptic location of nicotinic cholinergic binding sites on catecholamine and serotonin axons in the striatum and hypothalamus. |
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Keywords: | [3H]Acetylcholine binding sites Nicotinic cholinergic presynaptic receptors Brain |
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