A gene structure of testosterone 6 beta-hydroxylase (P450IIIA) |
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| Authors: | M Miyata K Nagata Y Yamazoe R Kato |
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| Affiliation: | Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan. |
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| Abstract: | Genomic clones of a rat testosterone 6 beta-hydroxylase have been isolated and characterized as the first gene (P450/6 beta A) among P450IIIA subfamily. This gene spans about 25Kb and consists of 13 exons, which is the largest number of exons among cytochrome P-450 genes reported previously. The nucleotide sequence of the exon region showed high similarity to those of P450PCN2 and P450PCN1 cDNA (Gonzalez, F.J. et al. (1987) Mol. Cell. Biol. 2969-2974), but several replacements and deletions of nucleotide were found between the P450/6 beta A gene and both cDNAs, indicating the existence of multiple P450IIIA genes in rats. |
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