Prostaglandins may play a signal-coupling role during phagocytosis in Amoeba proteus |
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| Authors: | Dr Robert D Prusch Stella-Maris Goette Paula Haberman |
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| Institution: | (1) Department of Life Sciences, Gonzaga University, Spokane, Washington, USA;(2) Department of Biological Sciences, Stanford University, Stanford, California, USA;(3) University of Washington, School of Medicine, Seattle, Washington, USA;(4) Department of Life Sciences, Gonzaga University, 99258 Spokane, Washington, USA |
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| Abstract: | Summary Phagocytosis in Amoeba proteus can be induced with prostaglandins (PG). In addition, arachidonic acid (the fatty acid precursor to the PG-2 series) also induces phagocytosis. The induction of phagocytosis with arachidonic acid can be partially inhibited by the cyclooxygenase inhibitor indomethacin. Phagocytosis in the amoeba can also be induced with the chemotactic peptide N-formylmethionyl-leucylphenylalanine (NFMLP). The peptide presumably induces phagocytosis by interacting with receptors on the amoeba surface, which may initiate the release of arachidonic acid from membrane lipids. NFMLP-induced phagocytosis can also be partially inhibited by indomethacin. It is suggested that PG's or biochemically related substances may play a signal-coupling role during phagocytosis in the amoeba. |
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| Keywords: | Phagocytosis Prostaglandins Amoeba proteus (Protozoa) |
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