Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura |
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Authors: | Arne May Roel A. Ophoff Gisela M. Terwindt Christine Urban Ronald van Eijk Joost Haan H. Christoph Diener Dick Lindhout Rune R. Frants Lodewijk A. Sandkuijl Michel D. Ferrari |
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Affiliation: | (1) Department of Neurology, Essen University, Germany;(2) MGC-Department of Human Genetics, Leiden University, Leiden, The Netherlands;(3) Department of Neurology, University Hospital, P.O.Box 9600, NL-2300 RC Leiden, The Netherlands;(4) Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands |
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Abstract: | Migraine is a common neurological disease of two main types: migraine with aura and migraine without aura. Familial clustering suggests that genetic factors are involved in the etiology of migraine. Recently, a gene for familial hemiplegic migraine, a rare autosomal dominant subtype of migraine with aura, was mapped to chromosome 19p13. We tested the involvement of this chromosomal region in 28 unrelated families with the common forms of migraine with and without aura, by following the transmission of the highly informative marker D19S394. Sibpair analysis showed that affected sibs shared the same marker allele more frequently than expected by chance. Our findings thus also suggest the involvement of a gene on 19p13 in the etiology of the common forms of migraine. |
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