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Damage of <Emphasis Type="Italic">Streptococcus mutans</Emphasis> biofilms by carolacton,a secondary metabolite from the myxobacterium <Emphasis Type="Italic">Sorangium cellulosum</Emphasis> |
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| Authors: | Brigitte Kunze Michael Reck Andreas Dötsch André Lemme Dietmar Schummer Herbert Irschik Heinrich Steinmetz Irene Wagner-Döbler |
| Institution: | 1.Group Microbial Communication,Helmholtz-Centre for Infection Research,Braunschweig,Germany;2.Group Chronic Pseudomonas Infections,Helmholtz-Centre for Infection Research,Braunschweig,Germany;3.Group Microbial Drugs,Helmholtz-Centre for Infection Research,Braunschweig,Germany;4.Sanofi-Aventis Deutschland GmbH,Natural Products,Germany |
| Abstract: | BackgroundStreptococcus mutans is a major pathogen in human dental caries. One of its important virulence properties is the ability to form biofilms (dental plaque) on tooth surfaces. Eradication of such biofilms is extremely difficult. We therefore screened a library of secondary metabolites from myxobacteria for their ability to damage biofilms of S. mutans. |
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