双歧杆菌诱发实验性大肠癌凋亡的电镜观察

本文以大肠癌裸鼠移植瘤为动物模型，用透射电镜观察了青春型双歧杆菌对移植瘤超微结构的影响。结果表明：双歧杆菌经荷瘤鼠腹腔注射后能诱导多量大肠癌细胞凋亡，凋亡早期的细胞主要表现为核染色质浓缩边聚；中期为核膜破裂，胞核崩解，凋亡小体形成；晚期主要为邻近活细胞吞噬凋亡小体。提示双歧杆菌诱导大肠癌细胞程序化死亡可能是其抑瘤机制之一。

AN ULTRASTRUCTURAL STUDY ON APOPTOSIS OF EXPERIMENTAL COLORECTAL CANCER CELLS INDUCED BY BIFIDOBACTERIUM

The effect of bifidobacterium adolescentis on the ultrastructure of transplantation tumors was observed depending on the animal model of nude mouse transplantation tumor of colorectal cancer.The results showed that this bacteria could induce apoptosis of tumor cells when injected into the peritoneum of tumor-bearing mouses. In early phase,its gross features of apoptotic cells present mainly nuclear chromatin condensation;In intermediate phase,it included mainly the cleavage of nuclear membrane and nuclei and the formation of apopotic bodies;In late phase,the apoptotic cells were phagocytized mainly by adjacent living cells. The results suggested that the programmed cell death of colorectal cancer induced by this bacteria may be one way of its inhibiting tumors.