Friend小鼠白血病病毒（Fr.MuLV）对新生金地鼠的感染性研究

一般认为，Ｆｒｉｅｎｄ小鼠白血病病毒（Ｆｒｉｅｎｄｍｕｒｉｎｅｌｅｕｋｅｍｉａｖｉｒｕｓ：Ｆｒ．ＭｕＬＶ）属同种嗜性白血病病毒（ｅｃｏｔｒｏｐｉｃＭｕＬＶ），只感染小鼠或大鼠，分别引起小鼠发生白血病和大鼠发生呆小病；但对小鼠或大鼠以外的动物（包括人等）无感染性。为进一步探讨该病毒的感染范围，本文进行了该病毒对金地鼠的感染性研究。结果表明，该病毒可在新生金地鼠体内增殖，引起新生金地鼠出现体重减轻、脾萎缩、并发早死等呆小病样症状，病理学检查发现接种该病毒后新生金地鼠的脾脏、胸腺呈明显的病理变化。提示Ｆｒ．ＭｕＬＶ对新生金地鼠具有感染作用，并产生病毒增殖和引起呆小病样症状，为阐明Ｆｒ．ＭｕＬＶ的感染范围和致病作用提供了实验依据。

STUDY ON INFECTION OF FRIEND MURINE LEUKEMIA VIRUS IN GOLDEN HAMSTER

t is Known that Friend murine leukemia virus (Fr MuLV) was a kind of ecotropic MuLV,it can infect murine and rat,and induce leukemiain murine and runting diseade in rat were generally considered can not be infected by Fr MuLV,we had observed the infection of Fr MuLV to golden hamster Results Showed that Fr MuLV could infect and proliferate in newboen golden hanster,and induced symptoms of runting disease ,for exanple,weight lose,spleen atrophy,early death,etc Some distinct pathological reaction could observed in spleen and thymus in inoculated newbom golden hamter according to pathological examination This study provides expeimental evident for the clarification of category of animal which can be infected by Fr MuLV