小鼠生态条件对Friend小鼠白血病病毒感染的影响

本文探讨了Ｆ１小鼠生态条件（鼠龄和免疫状态）对Ｆｒｉｅｎｄ小鼠白血病病毒（Ｆｒ．ＭｕＬＶ）感染的影响。利用对Ｆｒ．ＭｕＬＶ抗性的Ｆｖ４小鼠（含Ｆｖ４抗性基因纯合子的ＢＡＬＢ／Ｃ小鼠）与对Ｆｒ．ＭｕＬＶ敏感的ＢＡＬＢ／Ｃ小鼠交配，获得含Ｆｖ４抗性基因杂合子的Ｆ１小鼠（ＢＡＬＢ／Ｃ×Ｆｖ４）。然后经小鼠腹腔接种Ｆｒ．ＭｕＬＶ病毒液进行攻击，并检查不同鼠龄和免疫状态下的Ｆ１小鼠对Ｆｒ．ＭｕＬＶ的敏感性，以阐明Ｆ１小鼠的鼠龄和免疫状态对Ｆｒ．ＭｕＬＶ感染的影响。结果表明，新生Ｆ１小鼠可发生Ｆｒ．ＭｕＬＶ感染，脾脏中有大量病毒增殖，并引起白血病；免疫抑制剂Ｆｋ５０６投与下的成年Ｆ１小鼠亦可发生Ｆｒ．ＭｕＬＶ的感染，脾脏中有病毒增殖，但不引起白血病；而新生或成年Ｆｖ４小鼠以及成年Ｆ１小鼠可抵抗Ｆｒ．ＭｕＬＶ的感染，脾脏中无病毒增殖，不发病。说明Ｆ１小鼠的鼠龄和免疫状态等生态条件可影响其对Ｆｒ．ＭｕＬＶ感染的敏感性，并且可影响Ｆｖ４基因抗病毒作用。

EFFECT OF MOUSE ECOLOGICAL ELEMENTS ON INFECTION OF FRIEND MURINE LEUKEMIA VIRUS

The effect of F1 mouse ecological elements that include age and immune status on the infection of Friend Murine leukemia virus(Fr.MuLV) had been investigated in the paper.F1 mice (Fv 4 antiviral gene heterozygote) were the offspring of Fr.MuLV resistant Fv 4 mice (Fv 4 antiviral gene homozygote) and Fr.MuLV sensitive BALB/C mice.Fr.MuLV was injected intra abdominally to the newborn F1 mice and adult F1 mice which had been given immune inhibitor Fk506.Result showed that Fr.MuLV could infect newborn F1 mice,and Fr.MuLV could propagated in mice spleen,and caused leukemia;Fr.MuLV could also infect adult F1 mice which had treated with immune inhibitor Fk506.Whereas the newborn or adult Fv 4 mice,and adult F1 mice could resistant the infection of Fr.MuLV,no viral propagation could be observed in mice spleen.This result suggested the sensitivity of F1 mice on infection of Fr.MuLV was determined by murine ecological elements such as age and immune status.This antiviral effect of Fv 4 antiviral gene was influenced by age and immune status of mouse.This result provides experimental evidence for clarification of the antiviral mechanism of organism.