Chromosome aberrations in 450 sperm complements from eight controls and lack of increase after chemotherapy in two patients |
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Authors: | J Jenderny M L Jacobi A Rüger G Röhrborn |
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Institution: | (1) Institut für Humangenetik und Anthropologie der Universität, W-4000 Düsseldorf, Germany;(2) Institut für Humangenetik, Klinikum der CAU, Schwanenweg 24, W-2300 Kiel, Germany |
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Abstract: | Summary Four hundred fifty sperm complements from eight controls were analyzed. A conservative estimate of aneuploidy was 1.8% with a hyperhaploid rate of 0.9% (4/450). The overall frequency of structural aberrations was 8.9% (40/450). The proportion of X-bearing (47.5%) and Y-bearing (52.5%) sperm did not differ significantly. Sperm complements were analyzed from a cancer patient 9 months after poly chemotherapy (n = 63) and from a patient being treated with Imurek (azathioprine) (n = 30). There was no significant increase in the incidence of numerical and structural chromosome aberrations in the sperm of either patient. The percentages of X-bearing and Y-bearing sperm were not significantly different from the expected 50%. |
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