AMPK links energy status to cell structure and mitosis |
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| Authors: | Koh Hyongjong Chung Jongkyeong |
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| Institution: | National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Republic of Korea. hjkoh@kaist.ac.kr |
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| Abstract: | AMP-activated protein kinase (AMPK) is known as an important cellular energy sensor, but its in vivo role has not been fully understood. Recent studies provided surprising results that AMPK regulates cell polarity and mitosis under the control of tumour suppressor LKB1. Moreover, these newly found in vivo functions of AMPK are regulated by energy status in a cell autonomous manner. These findings provide novel insights into the physiological function of AMPK and the treatment of AMPK-related diseases such as cancer and diabetes. |
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| Keywords: | AMPK LKB1 MRLC MLC2 Energy status Cell polarity Mitosis |
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