Extensive deletions in the Q region of the mouse major histocompatibility complex |
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Authors: | Allison Eastman O'Neill Kathleen Reid Juan Carlos Garberi Margaret Karl Lorraine Flaherty |
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Institution: | (1) New York State Department of Health, Wadsworth Center for Laboratories and Research, 12201 Albany, NY, USA;(2) New York State Department of Health, Wadsworth Center for Laboratories and Research, Empire State Plaza, 12201 Albany, NY, USA |
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Abstract: | By use of Southern blot analyses and low copy number probes, the fine structure of the Q region of the mouse major histocompatibility complex was studied in more detail. With a probe recognizing the even-numbered genes Q4, Q6, and Q8, it was evident that Q4 and/or the regions flanking Q4 are polymorphic, whereas Q6 and Q8, and their flanking regions are nonpolymorphic. Perhaps the most noteworthy finding is that at least two strain haplotypes, H-2
k and H-2
f, possessed extensive deletions in the Q region. The most striking deletion was found in the H-2
f haplotype, where the QI through Q9 genes appear to be missing. Because of these extensive deletions the functional importance of the Q region is questioned. |
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