ADENYLATE CYCLASE ACTIVITY IN MOUSE VAGINAL EPITHELIUM. AGE RELATED CHANGES IN BASAL ENZYME ACTIVITY AND ESTRADIOL SENSITIVITY |
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Authors: | STENER KVINNSLAND JOHN-GUNNAR FORSBERG |
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Institution: | The Institute of Anatomy, Årstadvollen, Bergen, Norway |
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Abstract: | Using neonatal and immature female NMRI mice, age related variations in histochemically demonstrable adenylate cyclase activity were studied in the vaginal epithelium. Basal enzyme activity increased from day 3 to 6 after birth, only later to decrease. Almost no activity was seen on day 14. An estradiol induced increase in enzyme activity occurred in 3- and 6-day-old animals but not in 14-day-old animals. In spite of this difference both neonatal and 14-day-old animals respond to estradiol with an increased amount of a cellular product with antigenic properties specific for the cervicovaginal epithelium. The results are discussed in relation to estrogen induced irreversible effects in the neonatal cervicovaginal epithelium. |
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