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Calcium efflux parallel to total phosphate retention in rat liver mitochondria |
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| Authors: | F Rigoni L Panato R Deana |
| Affiliation: | 1. Department of Mechanical Engineering, Delhi Technological University, Bawana Road, Delhi 110042;2. Management Development Institute, Gurgaon, India 122007;3. Bristol Business School, University of the West of England (UWE), UK;4. Faculty of Accounting, Ton Duc Thang University, Ho Chi Minh City, Vietnam |
| Abstract: | Phosphate efflux from uncoupled rat liver mitochondria was completely inhibited when mersalyl plus butylmalonate and ATP were added to a sucrose suspending medium. Despite the total retention of phosphate a calcium efflux was observed even in presence of ruthenium red. Under the above conditions no phosphate is transported in association with the ADP/ATP carrier. While mersalyl completely blocked the phosphate release induced by ruthenium red or EGTA from coupled mitochondria it only partially inhibited the CA2+-efflux. The inhibition of Ca2+ efflux was almost completely abolished in the presence of acetate. The existence of a co-transport of Ca2+ associated with phosphate is discussed. |
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