The role of lymphotoxin in development and maintenance of secondary lymphoid tissues |
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Authors: | Tumanov Alexei V Kuprash Dmitry V Nedospasov Sergei A |
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Institution: | Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia. tumanov@imb.ac.ru |
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Abstract: | Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen-specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs. |
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