Sex,sex chromosomes and gene expression |
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| Authors: | Xuemei Lu Chung-I Wu |
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| Affiliation: | (1) Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beichen West Road, Chaoyang, Beijing, China;(2) Department of Ecology and Evolution, University of Chicago, 5801 South Ellis Avenue, Chicago, IL 60637, USA |
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| Abstract: | The X chromosome has fewer testis-specific genes than autosomes in many species. This bias is commonly attributed to X inactivation in spermatogenesis but a recent paper in BMC Biology provides evidence against X inactivation in Drosophila and proposes that somatic tissue- and testis- but not ovary-specific genes tend not to be located on the X chromosome. Here, we discuss possible mechanisms underlying this bias, including sexual antagonism and dosage compensation. |
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