| 快速检测尖锐湿疣组织中人乳头瘤病毒6型和11型DNA的研究 |
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| 引用本文： | 李明发,刘季和,等.快速检测尖锐湿疣组织中人乳头瘤病毒6型和11型DNA的研究[J].Virologica Sinica,1993,8(1):71-75. |
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| 作者姓名： | 李明发 刘季和 |
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| 作者单位： | [1]南京铁道医学院生物学教研室，南京210009 [2]中国医学科学院皮肤病研究所，南京 |
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| 摘 要： | 本文应用聚合酶链反应技术对30例人生殖器尖锐湿疣 组织中HPV6，11DNA的存在进行了检测研究。结果发现HPV6，HPV11DNA的阳性率分别为60×，90％HPV6，HPV11DNA双重检出率为53．3％，总阳性率达96．67％，本文结果证实HPV6，11的感染和尖锐湿疣的发生密切相关。本文检测方法具有快速、灵敏、特异性强的优点，为HPVDNA的检测及其分型研究提供了有效的手段。作者还对两例女阴假性湿疣进行PCR扩增，结果似乎不支持女阴假性湿疣的HPV感染的病因学。
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| 关 键 词： | 生殖器尖锐湿疣 女阴假性湿疣 人乳头瘤病毒 聚合酶链反应 快速检测 |
A Rapid Detection of Human Papillomavirus 6, 11 DNA in Condyloma Acuminatum |
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| Li Mingfa et al.A Rapid Detection of Human Papillomavirus 6, 11 DNA in Condyloma Acuminatum[J].中国病毒学(英文版),1993,8(1):71-75. |
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| Authors: | Li Mingfa |
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| Abstract: | The polymerase chain reaction (PCR) was applied to identify the human papillomavirus (HPV) 6 and 11 DNA in the spcimens from 30 patients with condyloma acuminatum. The positive percentage of HPV6, HPV11 DNA was 60%, 90%, respectively. 53.3% samples showed the presence of both HPV6 and HPV11 DNA. The total positive percentage was 96.7%. Our result supported the data presented previously that the HPV6 and HPV11 are strongly associated with condyloma acuminatum. The PCR proved to be a rapid, sensitive, highly specific for detection and typing of HPV DNA. The negative amplification result of two cases of atypical condyloma could contribute to the explanation of its etiology. |
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| Keywords: | Condyloma Acuminatum Atypical Condyloma Human Papillomavirus PCR |
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