Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol |
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| Authors: | Chin Lee Fang Kong Siew Ming Seng Hoi Ling Khoo Kong Soo Vikneswaran Rajamurthy Teoh Siang Guan Ahmad Munirah Khoo Soo Beng Alan Maah Mohd Jamil Ng Chew Hee |
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| Affiliation: | a Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, 53300 Kuala Lumpur, Malaysiab School of Chemical Science, Universiti Sains Malaysia, 11800 Penang, Malaysiac Molecular Pathology Unit, Cancer Research Center, Institute for Medical Research, 50588 Kuala Lumpur, Malaysiad Chemistry Department, University of Malaya, 50603 Kuala Lumpur, Malaysia |
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| Abstract: | The synthesis and characterization of two cobalt(II) complexes, Co(phen)(ma)Cl 1 and Co(ma)2(phen) 2, (phen = 1,10-phenanthroline, ma− = maltolate or 2-methyl-4-oxo-4H-pyran-3-olate) are reported herein. The complexes have been characterized by FTIR, CHN analysis, fluorescence spectroscopy, UV-visible spectroscopy, conductivity measurement and X-ray crystallography. The number of chelated maltolate ligands seems to influence their DNA recognition, topoisomerase I inhibition and antiproliferative properties. |
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| Keywords: | Cobalt(II) complexes DNA binding Anticancer Topoisomerase I Restriction enzyme |
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