A new Co(III)-hypocrellin B complex with enhanced photonuclease activity |
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Authors: | Sun Yi Hou Yuan-Jun Zhou Qian-Xiong Chen Jing-Rong Zhang Bao-Wen Wang Xue-Song |
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Institution: | a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR Chinab Graduate School of Chinese Academy of Sciences, Beijing 100049, PR China |
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Abstract: | Hypocrellin B (HB), a naturally occurring photosensitizer, has been extensively and intensively studied as a promising photodynamic therapy (PDT) agent. In this work, a new Co(III) complex Co2(HB)(tmp)4]4+ (tmp = 3,4,7,8-tetramethyl-1,10-phenanthroline) was designed and synthesized with HB as bridging ligand and tmp as terminal ligand. Co2HB(tmp)4]4+ exhibits improved water solubility, enhanced absorptivity in the phototherapeutic window, increased binding affinity and DNA photocleavage capability toward dsDNA with respect to HB. The photodynamic activity of Co2(HB)(tmp)4]4+ stems from its 1O2 photosensitization ability, in sharp contrast to Cu2(HB)(tmp)2]2+ which relies on superoxide anion radical (O2- ) and hydroxyl radical (·OH) to photocleave DNA, though the both complexes possess similar electrochemical properties. The remarkable difference between the photodynamic mechanisms of Co2(HB)(tmp)4]4+ and Cu2(HB)(tmp)2]2+ was discussed in detail. |
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Keywords: | Co(III) complex Hypocrellins DNA binding Chemical nuclease Photo nuclease |
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