Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes |
| |
| Authors: | Pivetta Tiziana Cannas Maria Dolores Demartin Francesco Castellano Carlo Vascellari Sarah Verani Gaetano Isaia Francesco |
| |
| Institution: | a Dipartimento di Scienze Chimiche, Università degli Studi di Cagliari, 09042 Monserrato (CA), Italyb Dipartimento di Scienze e tecnologie biomediche, Università degli Studi di Cagliari, 09042 Monserrato (CA), Italyc Dipartimento di Chimica Strutturale e Stereochimica Inorganica, Università degli Studi di Milano, 20133 Milano, Italyd Dipartimento di Chimica Inorganica e Analitica, Università degli Studi di Cagliari, 09042 Monserrato (CA), Italy |
| |
| Abstract: | The synthesis, crystal structures, physicochemical properties and complex formation constants of Cu(phen)2(L)](ClO4)2 complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal-bipyramidal geometry for all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometric measurements. Testing copper(II) complexes in mouse neuroblastoma N2a cells persistently infected with the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at nontoxic doses. |
| |
| Keywords: | Copper(II) complexes X-ray structure Complex formation constants Cytotoxicity |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
