One pot synthesis of Cu(II) 2,2'-bipyridyl complexes of 5-hydroxy-hydurilic acid and alloxanic acid: synthesis, crystal structure, chemical nuclease activity and cytotoxicity |
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| Authors: | Dixit Namrata Koiri R K Maurya B K Trigun S K Höbartner Claudia Mishra Lallan |
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| Institution: | a Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221 005, Indiab Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi-221 005, Indiac Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
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| Abstract: | A barbiturate derivative 1,5-dihydro-5-5-pyrimidine-2,4(1H,3H)-dionyl]-2H-chromeno2,3-d] pyrimidine-2,4(3H)-dione] (LH4) was allowed to react with 2,2′-bipyridyl-dinitrato-Copper(II)-dihydrate which provides two complexes, characterized as Cu(bpy)(L1)]·3H2O () and Cu(bpy)(L2)]·H2O (), where bpy = 2,2′-bipyridine, L1 = 5-hydroxy-hydurilic acid and L2 = alloxanic acid. In a separate reaction of LH4 with Cu(NO3)2·H2O another type of complex Cu(LH3)2·(H2O)2]·4H2O () is formed. The complexes were characterized by single crystal X-ray crystallography, physicochemical and electrochemical studies. The interaction of complexes 1 and 3 with DNA was monitored using absorption and emission titrations as well as circular dichroism spectroscopy. The complexes were found to cleave supercoiled plasmid DNA to nicked circular and linear DNA. Complexes 1 and 3 were also tested against T-cell lymphoma (Dalton lymphoma DL) and showed significant cytotoxic activity with IC50 values of ~ 9.0 nM and 0.6 nM. |
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| Keywords: | One pot synthesis Transformation of barbiturate derivative Chemical nuclease property Cytotoxicity studies |
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