Cigarette Smoke Inhibits Brain Mitochondrial Adaptations of Exercised Mice |
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Authors: | Ana Elisa Speck Daiane Fraga Priscila Soares Débora L Scheffer Luciano A Silva Jr" target="_blank">Aderbal S AguiarJr Emílio L Estreck Ricardo A Pinho |
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Institution: | 1.Laboratório Experimental de Doen?as Neurodegenerativas, Departamento de Farmacologia,Universidade Federal de Santa Catarina,Florianópolis,Brazil;2.Experimental Laboratory of Physiopathology, Postgraduate Program in Health Sciences, Health Sciences Unit,Universidade do Extremo Sul Catarinense,Criciúma,Brazil;3.Laboratory of Exercise Biochemistry and Physiology, Postgraduate Program in Health Sciences, Health Sciences Unit,Universidade do Extremo Sul Catarinense,Criciúma,Brazil |
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Abstract: | Physical exercise and smoking are environmental factors that generally cause opposite health-promoting adaptations. Both physical
exercise and smoking converge on mitochondrial adaptations in various tissues, including the pro-oxidant nervous system. Here,
we analyzed the impact of cigarette smoking on exercise-induced brain mitochondrial adaptations in the hippocampus and pre-frontal
cortex of adult mice. The animals were exposed to chronic cigarette smoke followed by 8 weeks of moderate-intensity physical
exercise that increased mitochondrial activity in the hippocampus and pre-frontal cortex in the non-smoker mice. However,
mice previously exposed to cigarette smoke did not present these exercise-induced mitochondrial adaptations. Our results suggest
that smoking can inhibit some brain health-promoting changes induced by physical exercise. |
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