The implantation of puromycin into the neurosecretory nuclei of the rat |
| |
Authors: | R N Saxena Masaru Wada Hideshi Kobayashi |
| |
Institution: | (1) Misaki Marine Biological Station, University of Tokyo, Misaki, Kanagawa-ken, Japan;(2) Present address: Department of Zoology, University of Delhi, Delhi 7, India |
| |
Abstract: | Summary Following the bilateral implantation of puromycin into the paraventricular nuclei of rats, the neurosecretory cells became atrophic and the amount of aldehyde-fuchsin (AF) positive material in the neural lobe decreased. In these rats, urine excretion and water intake increased remarkably. The supraoptic nuclei of the rats were not affected by this treatment. After the unilateral implantation of puromycin in the paraventricular nucleus, the neurosecretory cells of the implanted side became atrophic, while those of the unimplanted side hypertrophied. The neural lobe contained similar amounts of AF-positive material to those of the control rats with unilateral cholesterol implants. In the rats implanted bilaterally with puromycin immediately above the supraoptic nucleus, the neurosecretory cells of this nucleus contained little or no AF-positive material, and urine excretion and water intake increased greatly. The cells of the paraventricular nucleus remained unchanged in these rats. |
| |
Keywords: | Puromycin Paraventricular nucleus Supraoptic nucleus Neurosecretory material Urine excretion Water intake |
本文献已被 SpringerLink 等数据库收录! |
|