Kinetic independence between red cell anion exchange and urea transport |
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Authors: | O Fr?hlich S C Jones |
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Affiliation: | Emory University School of Medicine, Atlanta, GA 30322. |
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Abstract: | Urea equilibrium exchange fluxes were measured in human red cells under conditions which recruit the anion transporter into an outward-facing or an inward-facing state (with respect to the anion transport site). Regardless of these conditions, urea transport always occurred at the same rate: 41 +/- 2 mol.(kg cell solids.min)-1 with 1.5 M urea at 0 degrees C. These data suggest that the pathway on the band-3 protein which mediates anion transport is kinetically uncoupled from urea transport and is probably not involved in the transport of urea across the red cell membrane. |
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