|
|||||
|
|
Preparation of vinyl thymidine ester catalyzed by protease and its chemical polymerization |
|
| Authors: | Masaru Kitagawa Hong Fan Takao Raku Ryuichiro Kurane Yutaka Tokiwa |
| Affiliation: | (1) National Institute of Bioscience and Human-Technology, Higashi 1-1, Tsukuba, Ibaraki, 305-8566, Japan;(2) Konan Chemical Industry Co., Ltd., Takatsuki, Osaka, 569-0066, Japan |
| Abstract: | Transesterification reaction of 0.25 M thymidine with 1 M divinyladipate in dimethylformamide (DMF) was catalyzed by an alkaline protease (5 mg ml–1) from Streptomyces sp. (20 units mg–1 min) at 30 °C for 7 days to give 5 -O-vinyladipoyl thymidine (yield 77%) without formation of any by-products. Poly(vinyl alcohol) containing thymidine branches could be obtained by its free-radical polymerization. |
| Keywords: | alkaline protease polymerization Streptomyces sp. thymidine vinyl ester |
| 本文献已被 SpringerLink 等数据库收录！ | |