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Metagenomic analysis of bronchoalveolar lavage samples from patients with idiopathic interstitial pneumonia and its antagonic relation with Pneumocystis jirovecii colonization |
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| Authors: | Vicente Friaza,Carmen de la Horra,Mario J. Rodrí guez-Domí nguez,José Martí n-Juan,Enrique J. Calderó n,Rosa del Campo |
| Affiliation: | a Instituto de Biomedicina de Sevilla, Hospital Universitario, Virgen del Rocío, Seville, Spain b Servicios de Medicina Interna, Hospital Universitario, Virgen del Rocío, Seville, Spain c Neumología, Hospital Universitario Virgen del Rocío, Seville, Spain d CIBER de Epidemiología y Salud Pública (CIBERESP), Hospital Universitario Ramón y Cajal, Madrid, Spain e Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain |
| Abstract: | Idiopathic interstitial pneumonias are interstitial lung diseases of unknown etiology which prognosis is usually fatal. Microbiota associated to bronchoalveolar lavage from 20 patients with negative bacterial cultures was explored by 16S-rDNA PCR-DGGE, showing a clearly negative relation among the presence of P. jirovecii and bacterial colonization. This is the first report of in vivo antagonistic relation among fungi and bacteria. |
| Keywords: | PCR-DGGE Idiopathic interstitial pneumonia Pneumocystis jirovecii Metagenomic |
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