Characterization of the human 5-hydroxytryptamine1B receptor. |
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| Authors: | H Jin D Oksenberg A Ashkenazi S J Peroutka A M Duncan R Rozmahel Y Yang G Mengod J M Palacios B F O'Dowd |
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| Institution: | Department of Pharmacology, University of Toronto, Ontario, Canada. |
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| Abstract: | We report the cloning of a human gene encoding the 5-hydroxytryptamine1B receptor. The receptor has the characteristics of a G-protein-linked receptor and is most homologous to the human 5-HT1D receptor. This human 5-HT receptor gene, most abundantly expressed in striatum, is localized on chromosome 6, at 6q13, and the gene encoding the 5-HT1D receptor is localized on chromosome 1. Radioligand studies indicate that the affinity of 3H]5-HT is 16 +/- 2 nM. Drug competition studies indicate that the receptor displays high affinity (i.e. less than 40 nM) for 5-HT, 5-carboxyamidotryptamine, methiothepin, and metergoline. |
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