Ethanol, the choline requirement, methylation and liver injury |
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| Authors: | A J Barak D J Tuma H C Beckenhauer |
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| Institution: | 1. Liver Study Unit, Veterans Administration Medical Center, Omaha, NE 68105, USA;2. Departments of Biochemistry and Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA |
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| Abstract: | The findings obtained in this laboratory and others over the past decade are discussed in order to formulate a thesis, indicating the adverse action of ethanol on a vital methylation process in the liver. Evidence is shown that the rat may have a means of compensating for this impairment in methylation whereas humans do not have this same ability to protect against this action of ethanol. These considerations may offer a basis of why rats are apparently more resistant to alcoholic liver injury than humans. |
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