首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Tissue-specific requirements for FGF8 during early inner ear development
Authors:Elena Domínguez-Frutos  Victor Vendrell  Yolanda Alvarez  Laura Cecilia Zelarayan  Iris Lpez-Hernndez  Marian Ros  Thomas Schimmang
Institution:Elena Domínguez-Frutos, Victor Vendrell, Yolanda Alvarez, Laura Cecilia Zelarayan, Iris López-Hernández, Marian Ros,Thomas Schimmang,
Abstract:Several members of the FGF gene family have been shown to intervene from various tissue sources to direct otic placode induction and otic vesicle formation. In this study we define the roles of FGF8, found in different expression domains during this process, in mice and chickens. By conditional inactivation of Fgf8 in distinct tissue compartments we demonstrate that Fgf8 is required in the mesoderm and endoderm during early inner ear development. In the chicken embryo, overexpression of Fgf8 from various tissue sources during otic specification leads to a loss of otic tissue. In contrast ectopic overexpression of Fgf10, a major player during murine otic induction, does not influence otic vesicle formation in chicken embryos but results in the formation of ectopic structures with a non-otic character. This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates.
Keywords:Fibroblast growth factor  Otic vesicle  Otic placode  Mouse  Chicken
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号