Chronobiotic effect of melatonin following phase shift of light/dark cycles in the field mouseMus booduga |
| |
Authors: | M. Singaravel V. K. Sharma R. Subbaraj N. Gopukumar Nair |
| |
Affiliation: | (1) Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, 625021 Madurai, India |
| |
Abstract: | The objective of this study was to assess whether melatonin accelerates the re-entrainment of locomotor activity after 6 h of advance and delay phase shifts following exposure to LD 12:12 cycle (simulating jet-lag/shift work). An experimental group of adult male field mice Mus booduga were subjected to melatonin (1 mg/kg) through i.p. and the control group were treated with 50 % DMSO. The injections were administered on three consecutive days following 6h of phase advance and delay, at the expected time of “lights off”. The results show that melatonin accelerates the re-entrainment after phase advance (29%) when compared with control mice. In the 6 h phase delay study, the experimental mice (melatonin administered) take more cycles for re-entrainment (51%) than the control. Further, the results suggest that though melatonin may be useful for the treatment of jet-lag caused by eastward flight (phase advance) it may not be useful for westward flight (phase delay) jet-lag |
| |
Keywords: | Melatonin re-entrainment circadian rhythm locomotor activity Mus booduga |
本文献已被 SpringerLink 等数据库收录! |