Induction of erythroid differentiation in Friend murine erythroleukemic cells by inorganic selenium compounds. |
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Authors: | P S Ebert G I Malinin |
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Affiliation: | Laboratory of Molecular Virology National Cancer Institute, N.I.H. Bethesda, Maryland 20014 USA;Physics Department, Georgetown University Washington, D. C. 20057 USA |
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Abstract: | Inorganic selenium compounds are shown to be inducers of hemoglobin synthesis in malignant murine erythroleukemia (MEL) cells. SeO2 can induce hemoglobin synthesis at the concentration of butyric acid and the concentration of dimethylsulfoxide (DMSO), two potent inducers of erythroid differentiation in MEL cells. SeO2 and H2SeO3 showed an equivalent capacity to stimulate hemoglobin synthesis in three different MEL cell lines. The incorporation of 3H-glycine into hemoglobin was demonstrated in lysates of SeO2-induced MEL cells. |
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