Analgesia induced by combined action of Tramadol and microwave irradiation in somatic pain in mice |
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Authors: | E N Nesin E V Gura |
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Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
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Abstract: | In experiments on albino male mice weighing 24 to 32 g, we studied the suppression of the pain reaction induced by injection
of formalin into the dorsal surface of the foot, using a combination of injection of tramadol hydrochloride (Tramal) in a
dose of 0.42 mg/kg and irradiation of the acupuncture point (AP) E-36 with low-intensity microwaves (frequency 30 to 300 GHz
and power rate density 3·10−9 W/cm2). The combined use of tramadol injection and the action of microwaves on the AP led to a decrease in the duration of the
pain reaction (licking of the pain nidus), on average, by 58.2%, as compared with that in the control animal group. The analgesic
effect was more strong in the case of such a combination than after isolated injection of tramadol in doses of 0.83 and 0.42
mg/kg (by 14.4 and by 10.0%, respectively) and isolated microwave irradiation of the AP TA E-36 (by 48.7%). The data obtained
demonstrate the possibility of effective analgesia using a combination of microwave irradiation of the AP and the pharmacological
influence with a significant decrease in the dose of the analgesic.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 4, pp. 314–319, July–August, 2006. |
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Keywords: | tramadol hydrochloride microwaves acupuncture point formalin test behavioral phenomena |
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