Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate,the grey mouse lemur |
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Authors: | Fabien Pifferi Olène Dorieux Christian-Alexandre Castellano Etienne Croteau Marie Masson Martine Guillermier Nadja Van Camp Philippe Guesnet Jean-Marc Alessandri Stephen Cunnane Marc Dhenain Fabienne Aujard |
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Affiliation: | 2. CNRS, URA CEA CNRS 2210, Fontenay-aux-Roses, France;4. Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada;11. LZ, Versailles, France;8. Microbiologie de l''Alimentation au Service de la Santé Humaine, INRA de Jouy en Josas, Jouy en Josas Cedex, France |
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Abstract: | Decreased brain content of DHA, the most abundant long-chain n-3 polyunsaturated fatty acid (n-3 LCPUFA) in the brain, is accompanied by severe neurosensorial impairments linked to impaired neurotransmission and impaired brain glucose utilization. In the present study, we hypothesized that increasing n-3 LCPUFA intake at an early age may help to prevent or correct the glucose hypometabolism observed during aging and age-related cognitive decline. The effects of 12 months’ supplementation with n-3 LCPUFA on brain glucose utilization assessed by positron emission tomography was tested in young adult mouse lemurs (Microcebus murinus). Cognitive function was tested in parallel in the same animals. Lemurs supplemented with n-3 LCPUFA had higher brain glucose uptake and cerebral metabolic rate of glucose compared with controls in all brain regions. The n-3 LCPUFA-supplemented animals also had higher exploratory activity in an open-field task and lower evidence of anxiety in the Barnes maze.jlr Our results demonstrate for the first time in a nonhuman primate that n-3 LCPUFA supplementation increases brain glucose uptake and metabolism and concomitantly reduces anxiety. |
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Keywords: | brain glucose hypometabolism long-chain n-3 polyunsaturated fatty acids positron emission tomography imaging |
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